In the curve sections of horizontal wells in Mahu block Xinjiang Oilfield, there are a large number of brown mudstones in Lower Karamay Formation and interbedded brown mudstones in the target Baikouquan Formation. Due to the high sensitivity of the brown mudstone to the water content and the characteristics of the hydration and dispersion, it enables the WOB transferring problems with high risks of differential sticking when sliding drilling with WBM and PDM BHA. In response to the issues of differential sticking while drilling into the brown mudstones, by adjusting the concentration of acid and other additives, eight kinds of acid solution for sticking-releasing agent formulae have been formed. Through the soluble acid evaluation, 15% hydrochloric acid and 3% hydrofluoric acid formula has been used, which has the strongest acid corrosion dissolution ability on brown mudstone and fluorescent gray glutenite, and successfully applied in the two sticking accidents in Mahu block. Compared with the traditional foam oil based agent, the acid sticking-releasing agent has the advantages of less dosage, simple preparation, short time and high rate of sticking release, which provides a new choice for dealing with the differential sticking issues in the brown mudstone section.