Gudong oilfield has high water content with average integrated water content of 95 %, which seriously affects the benefits of oilfield development. In view of the relatively shallow water blocking depth, short validity period and poor selectivity of the plugging agent in Gudong Oilfield, combined with the requirements and characteristics of selective water plugging in oil wells, through physical model experiment, the plugging ability, selectivity and adaptability of two kinds of selective water shutoff agents, the swelling composite particle plugging agent and the filled polymer gel system are evaluated. After plugging, the comprehensive recovery is enhanced by 17.01%, the initial comprehensive water cut is reduced by 26% and the comprehensive plugging rate is 92.5%. At the same time, according to the characteristics of high water-cut oil wells, two selective water shutoff oil wells were tested in the field. Before the measures, the average single well produced 36.5t of fluid per day, produced 1.2t of oil per day, with water cut of 96.7%. After the measures, the average single well produced 39.6t of fluid per day and produced 2.9t of oil per day with water cut of 92.7%, and added 748.0 tons of oil, valid for 220 days. The experimental results show that the combination of the two types of plugging agent slug has obvious effect of water shutoff, and the effect of water reduction and oil increase has been realized to control water and stabilize oil well, which provides technical guidance for the subsequent rapid selection and control of plugging. It has good reference significance for plugging selection and control of high water cut oil well in the same type of reservoir.